Article
Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer.
PloS one - 1 Jan 2018
Huhn Stefanie, da Silva Filho Miguel I, Sanmuganantham Tharmila, Pichulik Tica, Catalano Calogerina, Pardini Barbara, Naccarati Alessio, Polakova-Vymetálkova Veronika, Jiraskova Katerina, Vodickova Ludmila, Vodicka Pavel, Löffler Markus W, Courth Lioba, Wehkamp Jan, Din Farhat V N, Timofeeva Maria, Farrington Susan M, Jansen Lina, Hemminki Kari, Chang-Claude Jenny, Brenner Hermann, Hoffmeister Michael, Dunlop Malcolm G, Weber Alexander N R, Försti Asta
Abstract excerpt
Nod-like receptors (NLRs) are important innate pattern recognition receptors and regulators of inflammation or play a role during development. We systematically analysed 41 non-synonymous single nucleotide polymorphisms (SNPs) in 21 NLR genes in a Czech discovery cohort of sporadic colorectal cancer (CRC) (1237 cases, 787 controls) for their association with CRC risk and survival. Five SNPs were found to be...
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