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Article

Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival.

Carcinogenesis - 1 Nov 2011

Slattery Martha L, Lundgreen Abbie, Bondurant Kristina L, Wolff Roger K

Abstract excerpt

Interferons (IFNs) are proteins involved in many functions including antiviral and antimicrobial response, apoptosis, cell cycle control and mediating other cytokines. IFN gamma (IFNG) is a proinflammatory cytokine that modulates many immune-related genes. In this study we examine genetic variation in IFNG, IFNGR1, IFNGR2 and interferon regulatory factors (IRFs) to determine associations with colon and rectal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21859832
DOI: 10.1093/carcin/bgr189
PMCID: PMC3204348

Genes

IFNG
IFNGR1
IFNGR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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