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Article

Mutations in the notch signalling pathway are associated with enhanced anti-tumour immunity in colorectal cancer.

Journal of cellular and molecular medicine - 1 Oct 2020

Wang Fei, Long Jie, Li Liang, Zhao Zhi-Bin, Wei Fang, Yao Yuan, Qiu Wen-Jing, Wu Zi-Xin, Luo Qing-Qing, Liu Wei, Quan Yi-Bo, Lian Zhe-Xiong, Cao Jie

Abstract excerpt

The Notch signalling pathway is involved in the development of several cancers, including colorectal cancer (CRC). However, whether mutations in this pathway could alter the CRC immunophenotype remains unknown. Here, we investigated the relationship between Notch signalling pathway mutations and the tumour immune microenvironment by analysing gene expression data from the GSE108989 single T cell RNA sequencing...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphocytes, Tumor-Infiltrating

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Share to Receptors, Notch

Share to T-Lymphocytes, Regulatory

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Source

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Identifiers

PMID: 32924269
DOI: 10.1111/jcmm.15867
PMCID: PMC7579712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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