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Article

Seizure-presenting IDH-wildtype glioblastoma and the upregulation of a synaptic signature.

Journal of neurosurgery - 1 Jul 2026

McDonald Malcolm F, Athukuri Prazwal, Khan A Basit, Goethe Eric A, English Collin, Lozzi Brittney, Harmanci Akdes Serin, Patel Akash J, Deneen Benjamin, Mandel Jacob J, Rao Ganesh

Abstract excerpt

OBJECTIVE: Epileptic activity is common throughout the glioma disease course and causes significant morbidity for patients. While its clinical impact on glioma has been analyzed, the underlying biological mechanisms of hyperactivity remain uncharacterized. Herein, the authors characterized the differences in epileptic activity across the disease course of various glioma subtypes based on tumor grade and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41962162
DOI: 10.3171/2025.11.JNS251412

Genes

SLC17A8
ADAMTS2
IGFN1
RELN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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