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Article

SLC7A11 Overexpression in Glioblastoma Is Associated with Increased Cancer Stem Cell-Like Properties.

Stem cells and development - 1 Sept 2017

Polewski Monika D, Reveron-Thornton Rosyli F, Cherryholmes Gregory A, Marinov Georgi K, Aboody Karen S

Abstract excerpt

System xc- is a sodium-independent electroneutral transporter, comprising a catalytic subunit xCT (SLC7A11), which is involved in importing cystine. Certain cancers such as gliomas upregulate the expression of system xc-, which confers a survival advantage against the detrimental effects of reactive oxygen species (ROS) by increasing generation of the antioxidant glutathione. However, ROS have also been shown to...

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Identifiers

PMID: 28610554
DOI: 10.1089/scd.2017.0123
PMCID: PMC5576215

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