Article
IDH1 mutation is associated with seizures and protoplasmic subtype in patients with low-grade gliomas.
Epilepsia - 1 Sept 2014
Liubinas Simon V, D'Abaco Giovanna M, Moffat Bradford M, Gonzales Michael, Feleppa Frank, Nowell Cameron J, Gorelik Alexandra, Drummond Katharine J, O'Brien Terence J, Kaye Andrew H, Morokoff Andrew P
Abstract excerpt
OBJECTIVE: The isocitrate dehydrogenase 1 (IDH1) R132H mutation is the most common mutation in World Health Organization (WHO) grade II gliomas, reported to be expressed in 70-80%, but only 5-10% of high grade gliomas. Low grade tumors, especially the protoplasmic subtype, have the highest incidence of tumor associated epilepsy (TAE). The IDH1 mutation leads to the accumulation of 2-hydroxyglutarate (2HG), a...
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