Article
Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer's Disease.
Molecular neurobiology - 1 Sept 2018
Ettcheto Miren, Sánchez-López Elena, Gómez-Mínguez Yaiza, Cabrera Henrry, Busquets Oriol, Beas-Zarate Carlos, García Maria Luisa, Carro Eva, Casadesus Gemma, Auladell Carme, Vázquez Carrera Manuel, Folch Jaume, Camins Antoni
Abstract excerpt
There is growing evidence that obesity associated with type 2 diabetes mellitus (T2DM) and aging are risk factors for the development of Alzheimer's disease (AD). However, the molecular mechanisms through which obesity interacts with β-amyloid (Aβ) to promote cognitive decline remains poorly understood. Memantine (MEM), a N-methyl-D-aspartate receptor antagonist, is currently used for the treatment of AD....
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