Genotypic tropism testing: evidence-based or leap of faith?

Abstract excerpt

Tropism testing in antiretroviral therapy HIV-1 tropism is largely determined by the specific chemokine co-receptor used in conjunction with the CD4 receptor for entry into target cells. In the early 1990s, the discovery of co-receptor use significantly advanced our understanding of virus–host interactions and disease pathogenesis in HIV infection. Work over the following decade identified a novel class of...