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In vitro phenotypic susceptibility of HIV-1 non-group M to CCR5 inhibitor (maraviroc): TROPI-CO study.

Microbiology spectrum - 2 Jul 2024

Gracias Ségolène, El Yaalaoui Ikrame, Visseaux Benoît, Charpentier Charlotte, Descamps Diane, Martin Charlène, Lermechain Fanny, Plantier Jean-Christophe, Alessandri-Gradt Elodie

Abstract excerpt

The susceptibility of genetically divergent HIV-1 strains (HIV-1 non-M) from groups O, N, and P to the CCR5 co-receptor antagonist, maraviroc (MVC), was investigated among a large panel of 45 clinical strains, representative of the viral genetic diversity. The results were compared to the reference strains of HIV-1 group M (HIV-1/M) with known tropism. Among the non-M strains, a wide range of phenotypic...

Topics

HIV-1
Maraviroc
Humans
CCR5 Receptor Antagonists
HIV Infections
Viral Tropism
Inhibitory Concentration 50
Triazoles
Phenotype
Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, CCR5

Anti-HIV Agents

Cyclohexanes

Drug Resistance, Viral

HIV Fusion Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 38809042
DOI: 10.1128/spectrum.03895-23
PMCID: PMC11218461

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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