Article
Determination of the high prevalence of Dual/Mixed- or X4-tropism among HIV type 1 CRF01_AE in Hong Kong by genotyping and phenotyping methods.
AIDS research and human retroviruses - 1 Aug 2013
To Sabrina Wai-Chi, Chen Jonathan Hon-Kwan, Wong Ka-Hing, Chan Kenny Chi-Wai, Chen Zhiwei, Yam Wing-Cheong
Abstract excerpt
In Hong Kong, the CCR5 antagonist has recently been introduced into salvage therapy for multiclass drug-resistant HIV-1-infected patients. Coreceptor usage must be determined prior to the usage of the CCR5 antagonist, which does not inhibit X4-tropic viruses. This study aimed to determine the tropism prevalence for HIV-1 subtypes B and CRF01_AE in Hong Kong. In addition, a modified promoter-PCR phenotypic assay...
Topics
- Genotype
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Hong Kong
- Humans
- Phenotype
- Polymerase Chain Reaction
- Position-Specific Scoring Matrices
- Prevalence