Tumour spheres with inverted polarity drive the formation of peritoneal metastases in patients with hypermethylated colorectal carcinomas.

doi:10.1038/s41556-017-0027-6

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Article

Tumour spheres with inverted polarity drive the formation of peritoneal metastases in patients with hypermethylated colorectal carcinomas.

Nature cell biology - 1 Mar 2018

Zajac Olivier, Raingeaud Joel, Libanje Fotine, Lefebvre Celine, Sabino Dora, Martins Isabelle, Roy Pétronille, Benatar Clara, Canet-Jourdan Charlotte, Azorin Paula, Polrot Mélanie, Gonin Patrick, Benbarche Salima, Souquere Sylvie, Pierron Gerard, Nowak Damien, Bigot Ludovic, Ducreux Michel, Malka David, Lobry Camille, Scoazec Jean-Yves, Eveno Clarisse, Pocard Marc, Perfettini Jean-Luc, Elias Dominique, Dartigues Peggy, Goéré Diane, Jaulin Fanny

Abstract excerpt

Metastases account for 90% of cancer-related deaths; thus, it is vital to understand the biology of tumour dissemination. Here, we collected and monitored >50 patient specimens ex vivo to investigate the cell biology of colorectal cancer (CRC) metastatic spread to the peritoneum. This reveals an unpredicted mode of dissemination. Large clusters of cancer epithelial cells displaying a robust outward apical pole,...

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PMID: 29403038
DOI: 10.1038/s41556-017-0027-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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