Article

Distinct cell states define the developmental trajectories of mucinous appendiceal neoplasms towards pseudomyxoma metastases

2022-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Appendiceal mucinous neoplasms (AMN) are rare tumors of the gastrointestinal tract. They metastasize with widespread abdominal dissemination leading to pseudomyxoma peritonei (PMP) , a disease with poor prognosis. The cellular features of origin, differentiation and progression in AMN and PMP remain largely unknown. We characterized the distinct cell states of AMN and PMP using single-cell RNA...

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Literature Corpus work: a7cc58c6-57ac-5e8e-949e-5c659fa1f3ed
DOI: 10.1101/2022.05.26.493618

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