Single‐cell and spatial omics unravel the spatiotemporal biology of tumour border invasion and haematogenous metastasis

Abstract excerpt

Solid tumours exhibit a well-defined architecture, comprising a differentiated core and a dynamic border that interfaces with the surrounding tissue. This border, characterised by distinct cellular morphology and molecular composition, serves as a critical determinant of the tumour's invasive behaviour. Notably, the invasive border of the primary tumour represents the principal site for intravasation of...

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