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Article

Engineering Escherichia coli for efficient production of 5-aminolevulinic acid from glucose.

Metabolic engineering - 1 Sept 2011

Kang Zhen, Wang Yang, Gu Pengfei, Wang Qian, Qi Qingsheng

Abstract excerpt

5-Aminolevulinic acid (ALA) recently received much attention due to its potential applications in many fields. In this study, we developed a metabolic strategy to produce ALA directly from glucose in recombinant Escherichia coli via the C5 pathway. The expression of a mutated hemA gene, encoding a glutamyl-tRNA reductase from Salmonella arizona, significantly improved ALA production from 31.1 to 176mg/L....

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Identifiers

PMID: 21620993
DOI: 10.1016/j.ymben.2011.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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