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Article

Engineering of high yield production of L-serine in Escherichia coli.

Biotechnology and bioengineering - 1 Apr 2016

Mundhada Hemanshu, Schneider Konstantin, Christensen Hanne Bjerre, Nielsen Alex Toftgaard

Abstract excerpt

L-serine is a widely used amino acid that has been proposed as a potential building block biochemical. The high theoretical yield from glucose makes a fermentation based production attractive. In order to achieve this goal, serine degradation to pyruvate and glycine in E. coli MG1655 was prevented by deletion of three L-serine deaminases sdaA, sdaB, and tdcG, as well as serine hydroxyl methyl transferase (SHMT)...

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PMID: 26416585
DOI: 10.1002/bit.25844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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