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Article

Effects of genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 on cyclosporine pharmacokinetics after renal transplantation.

Clinical and experimental pharmacology & physiology - 1 Nov 2006

Hu Yong-Fang, Qiu Wen, Liu Zhao-Qian, Zhu Li-Jun, Liu Zhong-Qi, Tu Jiang-Hua, Wang Dan, Li Zhi, He Jun, Zhong Gan-Ping, Zhou Gan, Zhou Hong-Hao

Abstract excerpt

1. The calcineurin inhibitor cyclosporine is widely used to prevent allograft rejection after solid organ transplantation. It has a narrow therapeutic index and shows considerable interindividual differences in its pharmacokinetics. Interindividual differences in the activity and expression of the metabolising enzymes cytochrome P450 (CYP) 3A4 and 3A5 and the multidrug efflux pump P-glycoprotein (P-gp) contribute...

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Identifiers

PMID: 17042920
DOI: 10.1111/j.1440-1681.2006.04492.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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