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Article

Association of CYP3A4*1B genotype with Cyclosporin A pharmacokinetics in renal transplant recipients: A meta-analysis.

Gene - 20 Jul 2018

Wang Cai-E, Lu Ke-Peng, Chang Zhao, Guo Meng-Li, Qiao Hai-Ling

Abstract excerpt

OBJECTIVE: Cyclosporine (CsA) is a substrate of cytochrome P450 (CYP) 3A4 with a narrow therapeutic index and large individual difference. CYP3A4*1B is reported to be associated with CsA pharmacokinetics parameters, but the relevance is still in dispute. Therefore, a meta-analysis was employed to evaluate the influence of CYP3A4*1B on CsA pharmacokinetics at different post-transplantation times in adult renal...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Cyclosporine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Graft Rejection

Share to Immunosuppressive Agents

Share to Kidney Failure, Chronic

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Source

Identifiers

PMID: 29678659
DOI: 10.1016/j.gene.2018.04.043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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