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Article

The Effect of ABCB1 C3435T Polymorphism on Cyclosporine Dose Requirements in Kidney Transplant Recipients: A Meta-Analysis.

Basic & clinical pharmacology & toxicology - 1 Aug 2015

Lee Jun, Wang Rongrong, Yang Yuan, Lu Xiaoyang, Zhang Xingguo, Wang Linrun, Lou Yan

Abstract excerpt

Cyclosporine A (CsA) is a substrate of the multi-drug efflux pump P-glycoprotein (P-gp) encoded by ABCB1. Among the various single nucleotide polymorphisms (SNPs) of ABCB1, C3435T has been extensively investigated to determine the relationship with the pharmacokinetics of CsA. However, the results are controversial. This meta-analysis was designed to evaluate the influence of C3435T SNP on the dose-adjusted...

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Identifiers

PMID: 25536375
DOI: 10.1111/bcpt.12371

Genes

ABCB1

Variants

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