Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients.

doi:10.2217/pgs-2017-0127

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Article

Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients.

Pharmacogenomics - 1 Nov 2017

Sun Bo, Guo Yankun, Gao Junwei, Shi Weifeng, Fan Guorong, Li Xiaoyu, Qiu Jianxin, Qin Yan, Liu Gaolin

Abstract excerpt

AIM: Cyclosporine is a substrate of CYP3A and ABCB1. This study examined the role of CYP3A and ABCB1 polymorphisms on cyclosporine pharmacokinetics in renal transplant recipients. PATIENTS & METHODS: CYP3A and ABCB1 SNPs were detected in 521 recipients. The relationships of dose-adjusted concentrations with corresponding genotypes were investigated at the different terms. RESULTS: CYP3A5 rs776746 and CYP3A7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28952408
DOI: 10.2217/pgs-2017-0127

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ABCB1

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