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Article

Protracted dormancy of pre-leukemic stem cells

28 May 2015

Abstract excerpt

Cancer stem cells can escape therapeutic killing by adopting a quiescent or dormant state. The reversibility of this condition provides the potential for later recurrence or relapse, potentially many years later. We describe the genomics of a rare case of childhood BCR-ABL1-positive, B-cell precursor acute lymphoblastic leukemia that relapsed, with an acute myeloblastic leukemia immunophenotype, 22 years after...

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PMID: 26017033
DOI: 10.1038/leu.2015.132

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