Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA-DR+ NK cells are mostly characterized by less mature phenotype and high functional activity.

Immunology and cell biology - 1 Feb 2018

Erokhina Sofya A, Streltsova Maria A, Kanevskiy Leonid M, Telford William G, Sapozhnikov Alexander M, Kovalenko Elena I

Abstract excerpt

NK cells change their phenotype and functional characteristics during activation. In this work, we searched for a relationship of HLA-DR expression with differentiation stages and functional activity of NK cells ex vivo and stimulated in vitro with IL-2 challenged with gene modified feeder K562 cells expressing membrane-bound IL-21 (K562-mbIL21). This stimulation technique has been described for NK cell expansion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cell Separation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to HLA-DR Antigens

Share to Interferon-gamma

Share to Interleukin-2

Share to K562 Cells

Share to Killer Cells, Natural

Source

Open in PubMed Open full text

Identifiers

PMID: 29363179
DOI: 10.1111/imcb.1032
PMCID: PMC8063572

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-DR+ NK cells are mostly characterized by less mature phenotype and high functional activity.PMID 29363179Read ↗

Analysis of NK cell clones obtained using interleukin-2 and gene-modified K562 cells revealed the ability of “senescent” NK cells to lose CD57 expression and start expressing NKG2ASemantic proximity Read ↗

Phenotypic and functional characterisation of locally produced natural killer cells ex vivo expanded with the K562-41BBL-mbIL21 cell lineSemantic proximity Read ↗

Human CD56bright NK Cells: An Update.Semantic proximity Read ↗

Phenotypic and functional characterisation of locally produced natural killer cells ex vivo expanded with the K562-41BBL-mbIL21 cell line.Semantic proximity Read ↗

An atlas of natural killer cell receptor expression on healthy donor T and NK lymphocytesSemantic proximity Read ↗

Human NK cell receptors/markers: a tool to analyze NK cell development, subsets and function.Semantic proximity Read ↗

NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.Semantic proximity Read ↗

A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature.Semantic proximity Read ↗

Chemokine Receptor Expression on Normal Blood CD56(+) NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population.Semantic proximity Read ↗

Multiple effects of IL-21 on human NK cells in ex vivo expansionSemantic proximity Read ↗

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.Semantic proximity Read ↗

Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.