Article
A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature.
Blood - 15 Jul 2007
Cooley Sarah, Xiao Feng, Pitt Michelle, Gleason Michelle, McCullar Valarie, Bergemann Tracy L, McQueen Karina L, Guethlein Lisbeth A, Parham Peter, Miller Jeffrey S
Abstract excerpt
How receptor acquisition correlates with the functional maturation of natural killer (NK) cells is poorly understood. We used quantitative real-time polymerase chain reaction (PCR) assays to compare NKG2 and killer immunoglobulin-like receptor (KIR) gene expression in NK cells from allogeneic transplant recipients and their donors. Marked differences were observed in the NK subsets of recipients who had 8-fold...
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