Article
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.
Blood - 11 Nov 2010
Björkström Niklas K, Riese Peggy, Heuts Frank, Andersson Sandra, Fauriat Cyril, Ivarsson Martin A, Björklund Andreas T, Flodström-Tullberg Malin, Michaëlsson Jakob, Rottenberg Martin E, Guzmán Carlos A, Ljunggren Hans-Gustaf, Malmberg Karl-Johan
Abstract excerpt
Natural killer (NK) cells are lymphocytes of the innate immune system that, following differentiation from CD56(bright) to CD56(dim) cells, have been thought to retain fixed functional and phenotypic properties throughout their lifespan. In contrast to this notion, we here show that CD56(dim) NK cells continue to differentiate. During this process, they lose expression of NKG2A, sequentially acquire inhibitory...
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