Article
NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.
PloS one - 6 Aug 2010
Béziat Vivien, Descours Benjamin, Parizot Christophe, Debré Patrice, Vieillard Vincent
Abstract excerpt
BACKGROUND: Terminal differentiation of NK cells is crucial in maintaining broad responsiveness to pathogens and discriminating normal cells from cells in distress. Although it is well established that KIRs, in conjunction with NKG2A, play a major role in the NK cell education that determines whether cells will end up competent or hyporesponsive, the events underlying the differentiation are still debated....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.