Article
Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells.
Stem cells and development - 1 Nov 2012
Lehmann Dorit, Spanholtz Jan, Osl Markus, Tordoir Marleen, Lipnik Karoline, Bilban Martin, Schlechta Bernhard, Dolstra Harry, Hofer Erhard
Abstract excerpt
Ex vivo differentiation systems of natural killer (NK) cells from CD34+ hematopoietic stem cells are of potential importance for adjuvant immunotherapy of cancer. Here, we analyzed ex vivo differentiation of NK cells from cord blood-derived CD34+ stem cells by gene expression profiling, real-time RT-PCR, flow cytometry, and functional analysis. Additionally, we compared the identified characteristics to...
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