Article
Serotonin receptor 1A promoter polymorphism, rs6295, modulates human anxiety levels via altering parasympathetic nervous activity.
Acta psychiatrica Scandinavica - 1 Mar 2018
Huang J-H, Chang H-A, Fang W-H, Ho P-S, Liu Y-P, Wan F-J, Tzeng N-S, Shyu J-F, Chang C-C
Abstract excerpt
OBJECTIVE: The G-allele of the -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (HTR1A) gene has been implicated in anxiety; however, the underlying neurophysiological processes are still not fully understood. Recent evidence indicates that low parasympathetic (vagal) tone is predictive of anxiety. We thus conducted a structural equation model (SEM) to examine whether the HTR1A rs6295 variant...
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