Article
The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system.
Journal of neurochemistry - 1 Nov 2006
Bruening S, Oh E, Hetzenauer A, Escobar-Alvarez S, Westphalen R I, Hemmings H C, Singewald N, Shippenberg T, Toth M
Abstract excerpt
A deficit in the serotonin 5-HT(1A) receptor has been found in panic and post-traumatic stress disorders, and genetic inactivation of the receptor results in an anxiety-like phenotype in mice on both the C57Bl6 and Swiss-Webster genetic backgrounds. Anxiety is associated with increased neuronal activity in the prefrontal cortex and here we describe changes in glutamate and GABA uptake of C57Bl6 receptor null...
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