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Article

Lack of evidence for selection favouring MHC haplotypes that combine high functional diversity.

Heredity - 1 May 2018

Gaigher Arnaud, Roulin Alexandre, Gharib Walid H, Taberlet Pierre, Burri Reto, Fumagalli Luca

Abstract excerpt

High rates of gene duplication and the highest levels of functional allelic diversity in vertebrate genomes are the main hallmarks of the major histocompatibility complex (MHC), a multigene family with a primordial role in pathogen recognition. The usual tight linkage among MHC gene duplicates may provide an opportunity for the evolution of haplotypes that associate functionally divergent alleles and thus grant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29362475
DOI: 10.1038/s41437-017-0047-9
PMCID: PMC5889407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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