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Article

Inbreeding does not reduce major histocompatibility complex diversity in the banded mongoose.

BMC ecology and evolution - 14 Oct 2025

Schubert Nadine, Nichols Hazel J, Mwanguhya Francis, Businge Robert, Kyambulima Solomon, Mwesige Kenneth, Cant Michael A, Winternitz Jamie C

Abstract excerpt

BACKGROUND: The major histocompatibility complex’s (MHC) role in the vertebrate adaptive immune response and its exceptional polymorphism make it a key target for studying adaptive gene evolution. However, studies on carnivore MHC often focus on populations with severe bottlenecks or conservation concerns, leading to small sample sizes and unreliable generalizations about MHC diversity. Furthermore, many studies...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41087899
DOI: 10.1186/s12862-025-02456-x
PMCID: PMC12519839

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