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Article

What evolutionary processes maintain MHC IIꞵ diversity within and among populations of stickleback?

Molecular ecology - 1 Apr 2021

Peng Foen, Ballare Kimberly M, Hollis Woodard S, den Haan Stijn, Bolnick Daniel I

Abstract excerpt

Major Histocompatibility Complex (MHC) genes code for proteins that recognize foreign protein antigens to initiate T-cell-mediated adaptive immune responses. They are often the most polymorphic genes in vertebrate genomes. How evolution maintains this diversity remains of debate. Three main hypotheses seek to explain the maintenance of MHC diversity by invoking pathogen-mediated selection: heterozygote advantage,...

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PMID: 33576071
DOI: 10.1111/mec.15840
PMCID: PMC8049082

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