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Article

Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity.

Immunogenetics - 1 Jan 2019

Otting Nel, de Groot Natasja G, Bontrop Ronald E

Abstract excerpt

Chimpanzees have been used for some time as an animal model in research on immune-related diseases in humans. The major histocompatibility complex (MHC) region of the chimpanzee has also been the subject of studies in which the attention was mainly on the class I genes. Although full-length sequence information is available on the DRB region genes, such detailed information is lacking for the other class II genes...

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PMID: 30159708
DOI: 10.1007/s00251-018-1080-4

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