Article
Contribution of mutation, recombination, and gene conversion to chicken MHC-B haplotype diversity.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2008
Hosomichi Kazuyoshi, Miller Marcia M, Goto Ronald M, Wang Yujun, Suzuki Shingo, Kulski Jerzy K, Nishibori Masahide, Inoko Hidetoshi, Hanzawa Kei, Shiina Takashi
Abstract excerpt
The Mhc is a highly conserved gene region especially interesting to geneticists because of the rapid evolution of gene families found within it. High levels of Mhc genetic diversity often exist within populations. The chicken Mhc is the focus of considerable interest because of the strong, reproducible infectious disease associations found with particular Mhc-B haplotypes. Sequence data for Mhc-B haplotypes have...
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