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Article

Methyltransferases of gentamicin biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America - 6 Feb 2018

Li Sicong, Guo Junhong, Reva Anna, Huang Fanglu, Xiong Binbin, Liu Yuanzhen, Deng Zixin, Leadlay Peter F, Sun Yuhui

Abstract excerpt

Gentamicin C complex from Micromonospora echinospora remains a globally important antibiotic, and there is revived interest in the semisynthesis of analogs that might show improved therapeutic properties. The complex consists of five components differing in their methylation pattern at one or more sites in the molecule. We show here, using specific gene deletion and chemical complementation, that the gentamicin...

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Identifiers

PMID: 29358400
DOI: 10.1073/pnas.1711603115
PMCID: PMC5819394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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