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Glycodiversification of gentamicins through <i>in vivo</i> glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity

2023-11-29

Abstract excerpt

Aminoglycosides (AGs) are a class of potent antibiotics with a broad spectrum of activity. However, their use is limited by safety concerns associated with nephrotoxicity and ototoxicity, as well as drug resistance. To address these issues, semi-synthetic approaches for modifying natural AGs have successfully generated new generations of AGs, however, with limited types of modification due to significant challenge...

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Literature Corpus work
bfeb21e1-3f87-5c70-b88a-26b1a9135d78
DOI
10.1101/2023.11.29.569180
Open publication

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Glycodiversification of gentamicins through <i>in vivo</i> glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicityDOI 10.1101/2023.11.29.569180
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