Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes in Kitasatospora sp. MBT66.

ACS chemical biology - 19 Feb 2016

Wu Changsheng, Medema Marnix H, Läkamp Rianne M, Zhang Le, Dorrestein Pieter C, Choi Young Hae, van Wezel Gilles P

Abstract excerpt

The increasing bacterial multidrug resistance necessitates novel drug-discovery efforts. One way to obtain novel chemistry is glycosylation, which is prevalent in nature, with high diversity in both the sugar moieties and the targeted aglycones. Kitasatospora sp. MBT66 produces endophenaside antibiotics, which is a family of (methyl-)rhamnosylated phenazines. Here we show that this strain also produces the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosyltransferases
Share to Macrolides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolic Networks and Pathways

Share to Methyltransferases

Share to Multigene Family

Share to Phenazines

Share to Substrate Specificity

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 26675041
DOI: 10.1021/acschembio.5b00801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes in Kitasatospora sp. MBT66.PMID 26675041Read ↗

How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical DiversitySemantic proximity Read ↗

Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide AntibioticsSemantic proximity Read ↗

GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discoverySemantic proximity Read ↗

Phylogeny-Informed Discovery of New Glycopeptide Antibiotics Produced by a Minimal Biosynthetic Gene ClusterSemantic proximity Read ↗

Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.Semantic proximity Read ↗

Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic superclusterSemantic proximity Read ↗

Biosynthetic Pathway for Mannopeptimycins, Lipoglycopeptide Antibiotics Active against Drug-Resistant Gram-Positive PathogensSemantic proximity Read ↗

Complete Characterization of the Seventeen Step Moenomycin Biosynthetic PathwaySemantic proximity Read ↗

In silico approaches illustrate the evolutionary pattern and protein-small molecule interactions of quinolone synthase from Aegle marmelos Correa.Semantic proximity Read ↗

Compartmentalized Biosynthesis of Mycophenolic AcidSemantic proximity Read ↗

The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase.Semantic proximity Read ↗

Midecamycin Is Inactivated by Several Different Sugar Moieties at Its Inactivation Site.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.