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The three‐dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin

8 Mar 2018

Abstract excerpt

The aminoglycoside antibiotics, discovered as natural products in the 1940s, demonstrate a broad antimicrobial spectrum. Due to their nephrotoxic and ototoxic side effects, however, their widespread clinical usage has typically been limited to the treatment of serious infections. Neomycin B, first isolated from strains of Streptomyces in 1948, is one such drug that was approved for human use by the U.S. Food and...

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PMID: 29516565
DOI: 10.1002/pro.3400

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