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Article

Epigenetic control of tetrapyrrole biosynthesis by m4C DNA methylation in a cyanobacterium.

DNA research : an international journal for rapid publication of reports on genes and genomes - 1 Dec 2024

Schmidt Nils, Stappert Nils, Nimura-Matsune Kaori, Watanabe Satoru, Sobotka Roman, Hagemann Martin, Hess Wolfgang R

Abstract excerpt

Epigenetic DNA modifications are pivotal in eukaryotic gene expression, but their regulatory significance in bacteria is less understood. In Synechocystis 6803, the DNA methyltransferase M.Ssp6803II modifies the first cytosine in the GGCC motif, forming N4-methylcytosine (GGm4CC). Deletion of the sll0729 gene encoding M.Ssp6803II (∆sll0729) caused a bluish phenotype due to reduced chlorophyll levels, which was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39657587
DOI: 10.1093/dnares/dsae035
PMCID: PMC11662147

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