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Identification of lethal mutations in Escherichia coli genes encoding enzymes of the methylerythritol phosphate pathway.

Biochemical and biophysical research communications - 25 Jul 2003

Sauret-Güeto Susanna, Ramos-Valdivia Ana, Ibáñez Ester, Boronat Albert, Rodríguez-Concepción Manuel

Abstract excerpt

The recently elucidated methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis is essential in eubacteria (including Escherichia coli), the malaria parasite, and plants, but is absent in animals. Therefore, the pathway enzymes are promising targets for the development of novel herbicides and antimicrobials that are potentially innocuous for humans. For an effective drug design, it is important to...

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PMID: 12859972
DOI: 10.1016/s0006-291x(03)01211-7

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