Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ApoL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase-2.

American journal of physiology. Renal physiology - 1 Jul 2018

Lee Hewang, Roshanravan Hila, Wang Ying, Okamoto Koji, Ryu Junghwa, Shrivastav Shashi, Qu Peng, Kopp Jeffrey B

Abstract excerpt

Apolipoprotein L1 ( ApoL1) genetic variants are strongly associated with kidney diseases. We investigated the role of ApoL1 variants in monocyte differentiation and eicosanoid production in macrophages, as activated tissue macrophages in kidney might contribute to kidney injury. In human monocyte THP-1 cells, transient overexpression of ApoL1 (G0, G1, G2) by transfection resulted in a 5- to 11-fold increase in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein L1
Share to Cyclooxygenase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dinoprostone

Share to Macrophage Activation

Share to Macrophages

Share to Monocytes

Share to THP-1 Cells

Share to Transforming Growth Factor beta1

Source

Open in PubMed Open full text

Identifiers

PMID: 29357411
DOI: 10.1152/ajprenal.00254.2017
PMCID: PMC6087794

Genes

TGFB1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ApoL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase-2.PMID 29357411Read ↗

The Apolipoprotein L1 Gene and Cardiovascular Disease.Semantic proximity Read ↗

APOL1-associated kidney disease: modulators of the genotype-phenotype relationship.Semantic proximity Read ↗

Monocyte- and endothelial-derived microparticles induce an inflammatory phenotype in human podocytes.Semantic proximity Read ↗

Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicitySemantic proximity Read ↗

APOL1 promotes endothelial cell activation beyond the glomerulusSemantic proximity Read ↗

APOL1 renal risk variants exacerbate podocyte injury by increasing inflammatory stressSemantic proximity Read ↗

LXRα is expressed at higher levels in healthy people compared to atherosclerosis patients and its over-expression polarizes macrophages towards an anti-inflammatory MΦ2 phenotype.Semantic proximity Read ↗

Human apolipoprotein L1 (ApoL1) in cancer and chronic kidney disease.Semantic proximity Read ↗

Native LDL promotes differentiation of human monocytes to macrophages with an inflammatory phenotype.Semantic proximity Read ↗

G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathwaySemantic proximity Read ↗

Variety matters: Diverse functions of monocyte subtypes in vascular inflammation and atherogenesisSemantic proximity Read ↗

Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.