Article
LXRα is expressed at higher levels in healthy people compared to atherosclerosis patients and its over-expression polarizes macrophages towards an anti-inflammatory MΦ2 phenotype.
Clinical and experimental hypertension (New York, N.Y. : 1993) - 1 Jan 2018
Liu Mengyuan, Yang Weijian, Liu Shuling, Hock Duncan, Zhang Bohao, Huo Ruth Ya, Tong Xiaoguang, Yan Hua
Abstract excerpt
OBJECTIVES: (1) To investigate the expression patterns of MΦ1 and MΦ2 phenotype markers of peripheral blood monocyte (PBMC)-derived macrophages in atherosclerosis patients and healthy controls, as well as the expression correlation among these genes. (2) To elucidate whether a high level of liver X receptor α (LXRα) expression is associated with anti-inflammatory MΦ2-type polarization. DESIGN: Peripheral blood...
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