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Article

Aberrant TGF-β activation in bone tendon insertion induces enthesopathy-like disease.

The Journal of clinical investigation - 1 Feb 2018

Wang Xiao, Xie Liang, Crane Janet, Zhen Gehua, Li Fengfeng, Yang Ping, Gao Manman, Deng Ruoxian, Wang Yiguo, Jia Xiaohua, Fan Cunyi, Wan Mei, Cao Xu

Abstract excerpt

Enthesopathy is a disorder of bone, tendon, or ligament insertion. It represents one-fourth of all tendon-ligament diseases and is one of the most difficult tendon-ligament disorders to treat. Despite its high prevalence, the exact pathogenesis of this condition remains unknown. Here, we show that TGF-β was activated in both a semi-Achilles tendon transection (SMTS) mouse model and in a dorsiflexion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29355842
DOI: 10.1172/JCI96186
PMCID: PMC5785263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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