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Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway

19 Jul 2021

Abstract excerpt

Abstract Acquired heterotopic ossification (HO) is the extraskeletal bone formation after trauma. Various mesenchymal progenitors are reported to participate in ectopic bone formation. Here we induce acquired HO in mice by Achilles tenotomy and observe that conditional knockout (cKO) offibroblast growth factor receptor 3(FGFR3) in Col2+cells promote acquired HO development. Lineage tracing studies reveal that...

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PMID: 34282140
DOI: 10.1038/s41467-021-24643-2

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