Article

New Insights into Neuromuscular Contracture Reveals Myotendinous-SMAD4 Signaling Underlies Contracture Formation

2024-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Neuromuscular contractures (NC) are a prevalent cause of joint deformity in children suffering from neuromuscular disorders or nerve damage, leading to persistent disability. The role of tendon in the development of NC remains poorly understood, with current treatments predominantly targeting muscle. Here, we establish a surgical model of NC in the hindlimb that recapitulates functional deformit...

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Literature Corpus work: b43a7edd-ce4d-539d-b4bf-f4ff78338d54
DOI: 10.1101/2024.06.11.598573

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