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Understanding of arthrofibrosis: New explorative insights into extracellular matrix remodeling of synovial fibroblasts

26 May 2023

Abstract excerpt

Arthrofibrosis following total knee arthroplasty is a fibroproliferative joint disorder marked by dysregulated biosynthesis of extracellular matrix proteins, such as collagens and proteoglycans. The underlying cellular events remain incompletely understood. Myofibroblasts are highly contractile matrix-producing cells characterized by increased alpha-smooth muscle actin expression and xylosyltransferase-I (XT-I)...

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PMID: 37235555
DOI: 10.1371/journal.pone.0286334

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