Exploring protein fitness landscapes by directed evolution.

doi:10.1038/nrm2805

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Article

Exploring protein fitness landscapes by directed evolution.

Nature reviews. Molecular cell biology - 1 Dec 2009

Romero Philip A, Arnold Frances H

Abstract excerpt

Directed evolution circumvents our profound ignorance of how a protein's sequence encodes its function by using iterative rounds of random mutation and artificial selection to discover new and useful proteins. Proteins can be tuned to adapt to new functions or environments by simple adaptive walks involving small numbers of mutations. Directed evolution studies have shown how rapidly some proteins can evolve...

Topics

Animals
Directed Molecular Evolution
Humans
Mutation
Proteins

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PMID: 19935669
DOI: 10.1038/nrm2805
PMCID: PMC2997618

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