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Article

Resident and Monocyte-Derived Macrophages in Cardiovascular Disease

4 Jan 2018

Abstract excerpt

Macrophages are ubiquitous cells that reside in all major tissues. Counter to long-held beliefs, we now know that resident macrophages in many organs are seeded during embryonic development and self-renew independently from blood monocytes. Under inflammatory conditions, those tissue macrophages are joined and sometimes replaced by recruited monocyte-derived macrophages. Macrophage function in steady state and...

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PMID: 29301844
DOI: 10.1161/circresaha.117.311071

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