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Article

Maturation of heart valve cell populations during postnatal remodeling

22 Feb 2019

Abstract excerpt

Heart valve cells mediate extracellular matrix (ECM) remodeling during postnatal valve leaflet stratification, but phenotypic and transcriptional diversity of valve cells in development is largely unknown. Single cell analysis of mouse heart valve cells was used to evaluate cell heterogeneity during postnatal ECM remodeling and leaflet morphogenesis. The transcriptomic analysis of single cells from postnatal day...

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PMID: 30796046
DOI: 10.1242/dev.173047

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