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Article

Loss of Axin2 results in impaired heart valve maturation and subsequent myxomatous valve disease.

Cardiovascular research - 1 Jan 2017

Hulin Alexia, Moore Vicky, James Jeanne M, Yutzey Katherine E

Abstract excerpt

AIMS: Myxomatous valve disease (MVD) is the most common aetiology of primary mitral regurgitation. Recent studies suggest that defects in heart valve development can lead to heart valve disease in adults. Wnt/β-catenin signalling is active during heart valve development and has been reported in human MVD. The consequences of increased Wnt/β-catenin signalling due to Axin2 deficiency in postnatal valve remodelling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28069701
DOI: 10.1093/cvr/cvw229
PMCID: PMC5220675

Genes

MVD

Provenance

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