Article
A novel subtype of sporadic Creutzfeldt-Jakob disease with PRNP codon 129MM genotype and PrP plaques.
Acta neuropathologica - 1 Jul 2023
Bayazid Rabeah, Orru' Christina, Aslam Rabail, Cohen Yvonne, Silva-Rohwer Amelia, Lee Seong-Ki, Occhipinti Rossana, Kong Qingzhong, Shetty Shashirekha, Cohen Mark L, Caughey Byron, Schonberger Lawrence B, Appleby Brian S, Cali Ignazio
Abstract excerpt
The presence of amyloid kuru plaques is a pathological hallmark of sporadic Creutzfeldt-Jakob disease (sCJD) of the MV2K subtype. Recently, PrP plaques (p) have been described in the white matter of a small group of CJD (p-CJD) cases with the 129MM genotype and carrying resPrPD type 1 (T1). Despite the different histopathological phenotype, the gel mobility and molecular features of p-CJD resPrPD T1 mimic those...
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