Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease

doi:10.1038/ctg.2017.58

Article

Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease

1 Jan 2018

Abstract excerpt

OBJECTIVES: Inflammatory bowel diseases (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are characterized by a complex pathophysiology that is thought to result from an aberrant immune response to a dysbiotic luminal microbiota in genetically susceptible individuals. New technologies support the joint assessment of host-microbiome interaction. METHODS: Using whole genome sequencing and...

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